Certain medications can cause fatigue as a side effect.

For example…

Antidepressants: Selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs) can cause fatigue as a side effect.

Blood pressure medications: Beta blockers, ACE inhibitors, and diuretics can cause fatigue.

Anti-anxiety medications: Benzodiazepines, such as Valium and Xanax, can cause fatigue.

Pain medications: Opioids, such as Oxycodone and Fentanyl, can cause fatigue.

Anti-seizure medications: Valproic acid, carbamazepine, and gabapentin can cause fatigue.

Hormone replacement therapy: Medications used to replace hormones, such as estrogen and progesterone, can cause fatigue.

Steroids: Prednisone and other steroid medications can cause fatigue.

Allergy Medications: Antihistamines can cause drowsiness and fatigue.

Statins: Medications used to lower cholesterol can cause fatigue as a side effect.

Anti-inflammatory medications: Non-steroidal anti-inflammatory drugs (NSAIDs) can cause fatigue as a side effect.

Medication side effects vary depending on the individual and the specific medication. If you suspect that a medication may be causing your fatigue, it’s important to speak with your healthcare provider about alternative medication options or ways to manage the side effect.

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Smiling Dr. Sarah Murphy stands with folded arms in a blue blouse near a doorway, with soft outdoor light and greenery behind her.

Dr. Sarah Murphy, NMD., L.Ac.

Dr. Sarah Murphy, NMD is an award-winning, licensed Naturopathic Doctor and Acupuncturist with more than 18 years of experience working in the areas of holistic, functional, and restorative medicine.